Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Aug 16;8:268. doi: 10.1038/s41467-017-00296-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — Multi-regional evolution. Cases with availability of multiple CT-guided samples were selected to analyze the phylogenetic relationship of clones from different regions. The location of samples is marked in the medical images in the right panel using the color code that was assigned to clones (left panel). The letter R indicates the right side of the body. a Four focal lesions (FL) showed similar genomic profiles, sharing the high-risk events bi-allelic deletion of CDKN2C, gain(1q) and del(17p). In contrast, a randomly biopsied non-FL site was low-risk and showed none of these events. b FLs displayed different genomic profiles with each of them containing unique driver mutations (BRAF, KRAS, and STAT3). Clones at the iliac crest and L1 contained different STAT3 mutations (STAT3^Asn553Lys vs. STAT3^Asp663Tyr). c Clones at T8 and the left iliac crest shared a missense NRAS mutation. Compared to the NRAS branch, the right iliac crest FL showed multiple site-specific CNAs and non-silent mutations. d Two major clones occupied four distant sites with the first clone being characterized by a non-ubiquitous IL6ST mutation. Moreover, an independent minor subclone with a missense KRAS mutation infiltrated both sites in the pelvis and T8, but not T12