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. 2017 Aug 16;7:8471. doi: 10.1038/s41598-017-08849-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of the constitutively active ADF/cofilin phospho-mutant (S3A) leads to the recovery of experience-driven synaptic AMPA receptor delivery in the barrel cortex of socially isolated rats. (a) Representative traces of neurons expressing RFP-S3A or RFP (control) in isolated or non-isolated rats. Scale bars 25 pA, 20 ms. Social isolation decreased the AMPA/NMDA ratio in neurons expressing RFP (isolated, n = 16; non-isolated, n = 23). The reduced AMPA/NMDA ratio was prevented in neurons expressing RFP-S3A (isolated, n = 15; non-isolated, n = 20). *P < 0.05 (ANOVA, F _(3,70) = 2.877). Error bars represent SEM. (b) Representative traces of neurons expressing HSV-S3A-IRES-Venus or HSV-IRES-Venus (control) from isolated or non-isolated rats. Scale bars 25 pA, 20 ms. S3A was expressed after the isolation period. Social isolation decreased the AMPA/NMDA ratio in neurons expressing HSV-IRES-Venus (isolated, n = 7; non-isolated, n = 11). The reduced AMPA/NMDA ratio was rescued in the neurons expressing HSV-S3A-IRES-Venus (isolated, n = 5; non-isolated, n = 6). *P < 0.05 (ANOVA, F _(3,25) = 4.550). Error bars represent SEM.