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. 2017 Aug 16;17(10):89. doi: 10.1007/s11892-017-0916-x

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Chromatin structure with histone modifications. Simplified schematic of the chromatin structure with histone modifications. Different modifications result in conformational changes to the chromatin. The nucleosome is made up of two copies of each histones H2A, H2B, H3 and H4, wrapped by 146 base pairs of DNA. Methylation of H3 on lysine at position 4, 36 and 79 leads to an actively transcribed open chromatin structure. Methylation at H3 on lysine at positions 9 and 27 leads to transcriptional repression. P phosphorylation, Ac acetylation, Me methylation

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