Table 3.
Data analysis
| Mean controla | Mean AMIb | p value | Cut-off level | TP | FP | TN | FN | PPVc | NPVd | |
|---|---|---|---|---|---|---|---|---|---|---|
| I-FABP Uden kit (ng/mL) | ||||||||||
| Block et al. [37] | 0.050 (0.0–0.197) | 0.186 (0.0–0.613) | 0.58 | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Cronk et al. [40] | 0.281 | 1.772 | N/A | 0.1 | 3 | 4 | 14 | 0 | 0.43 (0.10–0.82) | 1.00 (0.77–1.00) |
| Güzel et al. [41] | 0.08 (0.01–0.20) | 0.421 (0.040–5.0) | <0.001 | 0.09 | 24 | 0 | 30 | 3 | 1.00 (0.86–1.00) | 0.09 (0.02–0.24) |
| Thuijls et al. [46]f | 0.109 [0.04–1.691] | 0.653 [0.04–74.711] | 0.02 | 0.268 | 15 | 7 | 17 | 7 | 0.68 (0.45–0.86) | 0.71 (0.49–0.87) |
| Uzun et al. [47] | 0.170 ± 0.543 | 0.709 ± 0.669 | N/A | 0.145 | 5 | 9 | 155 | 2 | 0.36 (0.13–0.65) | 0.99 (0.95–1.00) |
| Vermeulen Windsant et al. [48] | N/A | N/A | N/A | 0.815 | 4 | 0 | 92 | 0 | 1.00 (0.40–1.00) | 1.00 (0.96–1.00) |
| van der Voort et al. [39]f | 1.020 | 2.872 | 0.98 | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| I-FABP Osaka kit (ng/mL) | ||||||||||
| Kanda et al. [15] | 25.1 ± 3.6 | 265.8 ± 111.3 | <0.0 | 100 | 7 | 0 | 48 | 6 | 1.00 (0.59–1.00) | 0.89 (0.77–0.96) |
| Kanda et al. [42] | 5.8 ± 15.6 | 40.7 ± 117.9 | <0.0001 | 3.1 | 41 | 81 | 228 | 11 | 0.34 (0.25–0.43) | 0.95 (0.92–0.98) |
| Kittaka et al. [43] | 1.6 | 18.5 | <0.001 | 6.5 | 15 | 1 | 15 | 6 | 0.94 (0.70–1.00) | 0.71 (0.48–0.89) |
| Matsumoto et al. [44] | 2.5 (0.2–56.7) | 31.0 (1.1–498.4) | <0.01 | 9.1 | 20 | 13 | 109 | 4 | 0.61 (0.42–0.77) | 0.96 (0.91–0.99) |
| Matsumoto et al. [45] | 3.2 [1.7–6.7] | 15.5 [5.3–52.9] | <0.001 | 9.7 | 19 | 6 | 37 | 8 | 0.76 (0.59 – 0.87) | 0.82 (0.72 – 0.89) |
| Shi et al. [38] | 33.9 ± 12.6 | 113.8 ± 46.3 | <0.001 | 93.07 | 30 | 59 | 174 | 9 | 0.34 (0.24–0.45) | 0.95 (0.91–0.98) |
| d-Lactate (mmol/L) | ||||||||||
| Block et al. [37] | 0.03 (0.02–0.07) | 0.05 (0.03–0.10) | 0.20 | 0.20 | 9 | 47 | 14 | 1 | 0.16 (0.08–0.28) | 0.93 (0.68–1.00) |
| Shi et al. [38]f | 0.15 ± 0.06 | 0.66 ± 0.29 | <0.001 | 0.38 | 26 | 33 | 200 | 13 | 0.44 (0.31–0.58) | 0.94 (0.90–0.97) |
| van der Voort et al. [39]e | 0.65 [0.37–0.94] | 0.79 (0.49–1.16) | 0.003g | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| 0.41 [0.11–0.75] | 0.56 (0.27–0.77) | 0.46h | ||||||||
| Murray et al. [53]f | 0.12 ± 0.04 | 0.36 ± 0.04 | <0.0005 | 0.22 | 8 | 1 | 19 | 3 | 0.89 (0.52–1.00) | 0.86 (0.65–0.97) |
| Assadian et al. [51] | 1.25 ± 0.61 | 3.03 ± 1.65 | 0.035 | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Poeze et al. [21] | 0.21 ± 0.06 | 0.32 ± 1.0 | <0.01 | 0.2 | 9 | 3 | 10 | 2 | 0.75 (0.43–0.95) | 0.83 (0.52–0.98) |
| α-GST (ng/ml) | ||||||||||
| Block et al. [37] | 1.3 (1.1–2.8) | 1.7 (0.7–4.2) | 0.21 | 4 | 2 | 9 | 53 | 8 | 0.18 (0.02–0.52) | 0.87 (0.76–0.94) |
| Gearhart et al. [55] | 2.2 (1.0–3.0) | 22.2 (7.0–126.0) | 0.001 | 4 | 25 | 4 | 15 | 10 | 0.86 (0.68–0.96) | 0.60 (0.39–0.79) |
| Delaney et al. [54] | 1.6 (0.8–2.2) | 75.8 (22.4–153.0) | <0.0001 | 4 | 12 | 2 | 12 | 0 | 0.86 (0.57–0.98) | 1.00 (0.74–1.00) |
| IMA (ABSU) | ||||||||||
| Polk et al. [57] | 0.31 ± 0.02 | 0.52 ± 0.04 | <0.0002 | 0.35 | 12 | 2 | 12 | 0 | 0.86 (0.57–0.98) | 1.00 (0.74–1.00) |
| Gunduz et al. [56] | 0.163 ± 0.025 | 0.264 ± 0.057 | 0.003 | 0.188 | 6 | 1 | 7 | 0 | 0.86 (0.42–1.00) | 1.00 (0.59–1.00) |
| Citrulline (nmol/ml) | ||||||||||
| Kulu et al. [58] | 32.8 ± 3.0 | 21.7 ± 3.1 | 0.01 | 15.8 | 9 | 0 | 25 | 14 | 1 | 0.64 (0.56–0.71) |
N/A not applicable, TP true positive, TN true negative, FP false positive, FN false negative, ABSU absorbance units
aNumbers between brackets represent 95% confidence intervals. Means are presented with standard deviation
bAcute mesenteric ischemia
cPositive predictive value
dNegative predictive value
eMedian [IQR] are presented
fValues were converted to mmol/L by multiplying by 0.0111
gIschemia vs. non-ischemia
hIschemia-likely vs. ischemia-unlikely