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. 2017 Aug 16;7:8480. doi: 10.1038/s41598-017-09095-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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miR-181a was involved in LTM formation following CFC and OLT by regulating PRKAA1. (a,b) Effects of different doses of the PRKAA1 agonist and inhibitor on the freezing response (a) and discrimination index (b) of mice 24 h after CFC or OLT training. *p < 0.05, **p < 0.01, compared with the vehicle group. n = 7 per group. (c–d) Freezing response when tested 24 h after CFC training. *p < 0.05, **p < 0.01, compared with the naïve group. ^# p < 0.05, compared with the CFC + miR-181a agomir group or CFC + miR-181a antagomir group. (e–f) Discrimination index 24 h after OLT training. *p < 0.05, **p < 0.01, compared with the naïve group. ^# p < 0.05, compared with the OLT + miR-181a agomir group or OLT + miR-181a antagomir group. CC, compound C. n = 8 per group. All values are presented as means ± SEM.