Table 4.
The potential sources of heterogeneity between LRP1 polymorphism and AD risk were evaluated by both of univariate and multivariate meta-regression analyses.
| Heterogeneity factors | Coefficient | 95% CI | SE | P |
|---|---|---|---|---|
| Age | ||||
| Univariate | 0.008 | (−0.027, 0.043) | 0.017 | 0.644 |
| Multivariate | −0.018 | (−0.051, 0.015) | 0.015 | 0.251 |
| Gender | ||||
| Univariate | 1.864 | (0.383, 3.345) | 0.712 | 0.016 |
| Multivariate | 2.193 | (0.233, 4.152) | 0.907 | 0.031 |
| MMSE | ||||
| Univariate | −0.081 | (−0.344, 0.182) | 0.127 | 0.532 |
| Multivariate | 0.004 | (−0.268, 0.277) | 0.126 | 0.975 |
| APOE ε4 status | ||||
| Univariate | −0.048 | (−0.440, 0.343) | 0.186 | 0.798 |
| Multivariate | 0.190 | (−0.252, 0.632) | 0.204 | 0.37 |
SE = standard error; 95%CI = 95% confidence interval.