Table 3.

Multivariate Cox analysis for factors potentially influence survival outcomes (FD, lacunarity separately).

Characteristic	PFS			OS
	p	HR	95%CI	p	HR	95%CI
FD
Age ≥ 50	0.032	1.684	1.044–2.716	0.012	1.854	1.143–3.006
KPS < 80	0.189	1.374	0.855–2.210	0.175	1.417	0.856–2.346
Volume ≥ 50 (cm3)	0.465	1.202	0.734–1.966	0.584	1.152	0.694–1.911
<GTR	0.043	1.594	1.014–2.506	0.005	1.947	1.223–3.101
RT plus TMZ	0.656	0.846	0.406–1.764	0.376	0.705	0.325–1.528
FD < 1.56	0.001	2.171	1.348–3.496	0.002	2.145	1.314–3.502
Lacunarity
Age ≥ 50	0.059	1.574	0.984–2.519	0.020	1.763	1.093–2.845
KPS < 80	0.019	1.737	1.095–2.756	0.069	1.592	0.965–2.626
Volume ≥ 50 (cm3)	0.618	1.133	0.694–1.851	0.852	1.049	0.631–1.744
<GTR	0.249	1.313	0.827–2.084	0.017	1.772	1.109–2.832
RT plus TMZ	0.398	0.733	0.357–1.505	0.261	0.645	0.300–1.386
Lacunarity > 0.46	0.015	1.746	1.114–2.736	0.007	1.891	1.186–3.014