Table 1.

Signaling differences and mutations in tumors that have either mutant p53 or loss of p16ink4a

Mutant p53	Loss of pl6
p42/44 MAPK possible tumor suppressor	p42/44 MAPK pro-tumorigenic
Negative for Wilms′ Tumor 1	Positive for Wilms′ Tumor 1
Ameboid morphology	Mesenchymal morphology
Lymph nodes	Hematogeneus
Radiation sensitive	Radiation resistant
Notch inactivate	Notch activation
Survivin	Superoxide
Stat 3	Stat 3/5
Hif1α	Hif2α
	Extracellular membrane deposition
	Increased telomerase

These represent polar opposites, but in some very advanced tumors, there may be both mutant p53 and loss of p16ink4a, leading to potential signaling plasticity