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Inhibition of Gq-mediated signalling.
| Compound | IC50 (μM) | pIC50 ± s.e.m. |
|---|---|---|
| YM-254890 (1) | 0.095 | 7.03 ± 0.02 |
| FR900359 (2, synthetic) | 0.033 | 7.49 ± 0.04 |
| FR900359 (2, isolated) | 0.032 | 7.50 ± 0.04 |
| YM-385780 (3) | 15.3 | 4.82 ± 0.03 |
| YM-385781 (4) | 1.54 | 5.82 ± 0.04 |
The inhibition of carbachol-induced IP1 production in CHO cells that stably express the M1 muscarinic receptor. IC50 values represent the mean of four independent experiments performed in triplicate.
