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. 2017 Aug 16;37(33):7824–7836. doi: 10.1523/JNEUROSCI.0691-17.2017

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Copyright © 2017 Wegner et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 6. — Phase-advancing effects of AMPA are enhanced in the Fbxl3^Afh/Afh SCN. A, Example traces of photomultiplier tube bioluminescence recordings from an Fbxl3^Afh/Afh (Afh/Afh) SCN explant treated with vehicle (black trace) or 5 μm AMPA (red trace) at the trough of day 5 in culture. The arrows indicate the point of peak expression used for calculation of the period, with red arrows delineating peaks pre- and post-AMPA treatment and black arrows showing peaks prevehicle and postvehicle control treatment. B, Compared with vehicle treatment, AMPA evoked significant phase advance in the timing of peak PER2::LUC bioluminescence in both Fbxl3^+/+ (+/+) and Fbxl3^Afh/Afh SCN explants. Larger advances were evoked by AMPA in Fbxl3^Afh/Afh compared with Fbxl3^+/+ SCN explants (5.1 ± 0.9 vs 2.5 ± 0.4 h, p = 0.0018), sample sizes given in brackets. *p < 0.05, **p < 0.01.