Figure 3.

rIL-1Ra treatment reduces subacute seizure severity after pTBI. Mice underwent severe (A, B) or moderate (C, D) TBI at P21, then received either rIL-1Ra (100 mg/kg, s.c.) or saline vehicle at 2, 8, and 24 h post-injury, followed by a PTZ challenge at 2 weeks. Alternatively, rIL-1Ra was administered 1 h before PTZ (E, F). After both severe and moderate TBI followed by acute drug administration (B, D), but not after delayed administration (F), rIL-1Ra treatment reduced seizure severity compared with vehicle treatment. Red dotted line indicates the median sham score (from Fig. 1A). n = 7–15/group; Mann–Whitney tests, *p < 0.05, **p < 0.01.