Table 1.

Open field behavioral analysis of line Kctd1 ^I27N

Parameter	Heterozygous mutant males	Wild-type males	Heterozygous mutant females	Wild-type females	Genotype: P-value
Distance traveled – total (cm)	8834 ± 2939	10,050 ± 2329	9823 ± 2178	10,138 ± 2682
Number of rearings - total	46 ± 41	75 ± 42	56 ± 45	74 ± 44	0.04
Percent distance in the center – total	10.4 ± 8.5	13.1 ± 7.3	12.5 ± 9.3	14.7 ± 8.3
Percent time spent in the center - total	6.9 ± 6.1	9.0 ± 5.6	8.8 ± 7.9	10.2 ± 6.5
Whole arena - resting time (sec)	47 ± 38	79 ± 36	70 ± 57	95 ± 58	0.03
Whole arena - average speed (cm/s)	7.7 ± 2.7	9.0 ± 2.3	8.8 ± 2.2	9.3 ± 2.8
Latency to enter in the center (sec)	349 ± 377	125 ± 209	122 ± 228	81 ± 137	0.047
Number of entries in the center	59 ± 51	76 ± 45	77 ± 57	87 ± 54

9-week-old mice were tested in the open field for 20 min. Number per genotype and sex: n = 15. Data are presented as mean ± standard deviation. Significance vs. wild-type controls: Exact P values are indicated for P < 0.05