Table 3.

Cardiovascular analysis of line Kctd1 ^I27N by echocardiography

Parameter	Heterozygous mutant males	Wild-type males	Heterozygous mutant females	Wild-type females	Genotype: P-value
IVSs (mm)	0.55 ± 0.03	0.55 ± 0.02	0.55 ± 0.02	0.54 ± 0.02
IVSd (mm)	0.54 ± 0.02	0.54 ± 0.02	0.55 ± 0.02	0.54 ± 0.02	0.04
LVPWs (mm)	0.54 ± 0.03	0.54 ± 0.02	0.54 ± 0.02	0.54 ± 0.02
LVPWd (mm)	0.54 ± 0.03	0.56 ± 0.02	0.54 ± 0.01	0.55 ± 0.02	0.03
LVIDs (mm)	1.39 ± 0.49	1.44 ± 0.60	1.53 ± 0.56	1.69 ± 0.46
LVIDd (mm)	2.87 ± 0.43	2.87 ± 0.57	2.85 ± 0.47	2.98 ± 0.32
Heart rate (bpm)	579 ± 114	530 ± 150	474 ± 167	453 ± 122
Respiration rate (1/min)	264 ± 36	250 ± 29	224 ± 50	238 ± 52
Body weight (g)	31.3 ± 1.4	32.3 ± 1.9	26.8 ± 1.6	27.1 ± 2.1

15-week-old mice were tested. Number per genotype and sex: n = 14–15. Data are presented as mean ± standard deviation. Significance vs. wild-type controls: Exact P values are indicated for P < 0.05

IVSs interventricular septum in systole, IVSd interventricular septum in diastole, LVPWs left ventricular posterior wall in systole, LVPWd left ventricular posterior wall in diastole, LVIDs left ventricular internal dimension in systole, LVIDd left ventricular internal dimension in diastole