Table 1.
Demographic and clinical characteristics of patients with multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis in Hunan Province, China, from 2011 to 2014
| Characteristics | Total n = 481 |
MDR-TBa
n = 471 |
XDR-TBb
n = 10 |
P-value* |
|---|---|---|---|---|
| Age in years, mean ± SDa | 40.4 ± 12.9 | 40.4 ± 12.9 | 40.6 ± 11.3 | 0.85 |
| Male gender, n (%) | 340 (70.7) | 331 (70.3) | 9 (90.0) | 0.29 |
| Occupation, n (%) | 0.11 | |||
| Farmer | 380 (79.0) | 374 (79.4) | 6 (60.0) | |
| Labourer | 15 (3.1) | − | ||
| Employed | 16 (3.3) | 15 (3.2) | − | |
| Unemployed | 19 (3.8) | 16 (3.4) | − | |
| Other/unknown | 51 (10.6) | 19 (4.0) 47 (10.0) |
4 (40.0) | |
| Year treatment commenced, n (%) | 0.10 | |||
| 2011 | 2 (0.4) | 2 (0.4) | − | |
| 2012 | 118 (24.5) | 116 (24.2) | 4 (40.0) | |
| 2013 | 164 (34.1) | 159 (33.7) | 5 (50.0) | |
| 2014 | 197 (40.9) | 196 (41.6) | 1 (10.0) | |
| Positive sputum smear result at commencement, n (%) | 477 (99.1) | 467 (99.1) | 10 (100.0) | 0.91 |
| Previous TB or MDR-TB treatment, n (%) | 417 (86.7) | 408 (86.6) | 9 (90.0) | 0.60 |
| Resistant number of drugs, median (IQR) | 3 (2–4) | 3 (2–4) | 5 (5–6) | 0.05 |
| Resistant to Ethambutol (E), n (%) | 165 (34.3) | 161 (34.2) | 4 (40.0) | 0.80 |
| Resistant to Streptomycin (S), n (%) | 288 (59.9) | 279 (59.2) | 9 (90.0) | 0.19 |
| Resistant to Ofloxacin (Ofx), n (%) | 46 (9.6) | 37 (7.9) | 9 (90.0) | <0.001 |
| Resistant to Kanamycin (Km), n (%) | 15 (3.1) | 6 (1.3) | 9 (90.0) | <0.001 |
| Treatment outcome, n (%) | 0.14 | |||
| Cured | 261 (54.3) | 258 (54.8) | 3 (30.0) | |
| Completed | 14 (2.9) | 14 (2.9) | − | |
| Successful treatment (cured + completed) | 275 (57.2) | 272 (57.8) | 3 (30.0) | |
| Died | 13 (2.7) | 13 (2.8) | − | |
| Failure | 63 (13.1) | 60 (12.7) | 3 (30.0) | |
| Poor treatment outcome (death + failure) | 76 (15.8) | 73 (15.5) | 3 (30.0) | |
| Lost to follow up | 130 (27.0) | 126 (26.8) | 4 (40.0) | |
| Unfavourable outcome (died + failure +lost to follow-up) | 206 (42.8%) | 199 (42.3) | 7 (70) | |
| Duration of therapy in months, median (IQRc) | 24 (13–25) | 24 (13–25) | 22.5 (14–26) | 0.87 |
| Sputum smear conversion, n (%) | 414 (86.1) | 404 (85.8) | 10 (100) | 0.37 |
| Culture conversion, n (%) | 386 (80.2) | 380 (80.7) | 6 (60.0) | 0.11 |
| Time of sputum smear conversion in months, median (IQRc) | 1(1–2) | 1(1–2) | 1.5 (1–8) | 0.37 |
| Time of culture conversation in months, median (IQRc) | 1 (1–3) | 1 (1–2) | 5 (1–20) | 0.03 |
a MDR-TB multidrug resistant tuberculosis, SD standard deviation, bXDR-TB, extensively drug-resistant tuberculosis
c IQR inter quartile range
*Comparison between MDR-TB and XDR-TB patients calculated with Wilcoxon rank-sum test for continuous variables and Fisher’s exact test for categorical variables