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. 2017 Aug 16;18:626. doi: 10.1186/s12864-017-4035-5

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — IPA of RNA-Seq data revealed a gene network controlled by the lipogenic transcription factors SREBF1 and SREBF2 (a). Panel b shows additional direct gene targets that are either unique to, or shared by, SREBF1 (35 DE genes) and SREBF2 (16 DE genes). The Ingenuity® Upstream Analysis predicates activation (orange arrows and symbols) or inhibition (blunt blue line) of direct target genes. The predicted activated (orange arrows) or inhibited (blunt blue lines) state of DE target genes is based on the expected responses accrued in the Ingenuity Knowledge Base