Table 1.
Patient characteristics in Harborview Medical Center cohort with systemic inflammatory response syndrome
| Clinical variables | No AKI | AKI | Total | |
|---|---|---|---|---|
| Resolving AKI | Nonresolving AKI | |||
| Total | 373 | 502 | 366 | 1241 |
| Baseline demographics | ||||
| Age, years | 53 ± 17 | 55 ± 15 | 55 ± 17 | 54 ± 16 |
| Male sex, n (%) | 233 (63) | 323 (64) | 250 (68) | 806 (65) |
| Body mass index, kg/m2 | 29.4 ± 10.2 | 31.2 ± 16.5 | 32.0 ± 19.4 | 30.8 ± 15.6 |
| Race, n (%) | ||||
| Caucasian | 267 (77) | 360 (76) | 272 (79) | 899 (77) |
| African American | 41 (12) | 66 (14) | 29 (8) | 136 (12) |
| Asian | 26 (7) | 35 (7) | 29 (8) | 90 (8) |
| Native American | 15 (4) | 13 (3) | 14 (4) | 42 (4) |
| Unknown | 24 (6) | 28 (6) | 22 (6) | 74 (6) |
| APACHE III (24 h) | 38 ± 18 | 57 ± 27 | 55 ± 27 | 50 ± 26 |
| Comorbidities, n (%) | ||||
| Diabetes mellitus | 78 (21) | 167 (33) | 98 (27) | 343 (28) |
| Cirrhosis | 37 (10) | 39 (8) | 38 (10) | 114 (9) |
| Chronic kidney disease | 16 (4) | 55 (11) | 43 (12) | 114 (9) |
| Congestive heart failure | 17 (5) | 58 (12) | 24 (7) | 99 (8) |
| Chronic obstructive lung disease | 64 (17) | 82 (16) | 59 (16) | 205 (17) |
| ICU events | ||||
| Mechanical ventilation (72 h) | 178 (48) | 354 (71) | 261 (71) | 793 (64) |
| Vasopressors (72 h) | 39 (10) | 140 (28) | 108 (30) | 287 (23) |
| Sepsis-2 | 227 (61) | 348 (69) | 268 (73) | 843 (68) |
| Sepsis-3 | 190 (51) | 287 (57) | 242 (66) | 719 (58) |
| Septic shock | 34 (14) | 122 (24) | 90 (25) | 246 (20) |
| Admission Scr | 0.8 ± 0.4 | 1.9 ± 1.7 | 1.6 ± 1.9 | 1.5 ± 1.6 |
| Maximum SCr (72 h) | 0.8 ± 0.4 | 2.0 ± 1.8 | 2.2 ± 2.4 | 1.7 ± 1.8 |
| KDIGO stage of AKI | ||||
| Stage 0 | 373 (100) | N/A | N/A | 373 (30) |
| Stage 1 | N/A | 219 (44) | 158 (43) | 377 (30) |
| Stage 2 | N/A | 155 (31) | 91 (25) | 250 (20) |
| Stage 3 | N/A | 128 (26) | 117 (32) | 245 (20) |
Abbreviations: AKI Acute kidney injury, APACHE III Acute Physiology and Chronic Health Evaluation III, ICU Intensive care unit, KDIGO Kidney Disease: Improving Global Outcomes, SCr Serum creatinine
Data are shown as mean ± SD, number of subjects (%), or median (IQR), as appropriate