Table 3.
Plasma biomarker concentrations by acute kidney injury subphenotype
| Biomarker | No. of patients | Biomarker concentration, median (IQR) | |||
|---|---|---|---|---|---|
| No AKI | Resolving AKI | Nonresolving AKI | Resolving versus nonresolving (p value) | ||
| Endothelial dysfunction | |||||
| Ang-1, pg/ml | 1212 | 6382 (3114, 10,409) | 4393 (1957, 8856) | 4033 (1638, 8048) | 0.315 |
| Ang-2, pg/ml | 1221 | 7985 (4636, 14,996) | 14,924 (8367, 29,425) | 15,126 (7047, 35,138) | 0.287 |
| Ang-2/Ang-1 | 1212 | 1.3 (0.6, 3.5) | 3.6 (1.1, 12.4) | 3.6 (1.1, 18.1) | 0.039 |
| sVCAM-1, ng/ml | 1222 | 481 (382, 687) | 530 (388, 783) | 571 (446, 842) | 0.023 |
| Apoptosis and inflammation | |||||
| sTNFR-1, pg/ml | 1161 | 5380 (3961, 8000) | 10,063 (6147, 15,566) | 9838 (5765, 18,358) | 0.010 |
| sFas, pg/ml | 1223 | 8810 (6880, 11,926) | 11,586 (8095, 15,700) | 12,879 (8938, 17,682) | 0.001a |
| IL-6, pg/ml | 1149 | 75 (31, 178) | 137 (59, 351) | 147 (58, 375) | 0.536 |
| IL-8, pg/ml | 1160 | 11 (5, 20) | 13 (7, 35) | 14 (7, 33) | 0.420 |
Abbreviations: AKI Acute kidney injury, Ang-1 Angiopoietin 1, Ang-2 Angiopoietin 2, IL Interleukin, sFas Soluble Fas, sTNFR-1 Soluble tumor necrosis factor receptor 1, sVCAM-1 Soluble vascular cell adhesion molecule 1
a p < 0.00625 based on Bonferroni correction for multiple hypotheses