Table 4.
Associations between biomarker levels and risk of nonresolving acute kidney injury subphenotype
| Biomarkers | Unadjusted RRa (95% CI) | p Value | Adjustedb model A, RR (95% CI) | p Value | Adjusted model B, RR (95% CI) | p Value |
|---|---|---|---|---|---|---|
| Endothelial dysfunction | ||||||
| Ang-1 | 0.96 (0.91, 1.00) | 0.068 | 0.96 (0.91, 1.00) | 0.073 | 0.95 (0.91, 1.00) | 0.049 |
| Ang-2 | 1.00 (0.95, 1.07) | 0.850 | 0.99 (0.94, 1.06) | 0.851 | 1.00 (0.94, 1.07) | 0.923 |
| Ang-2/Ang-1 | 1.04 (1.00, 1.08) | 0.029 | 1.02 (0.98, 1.05) | 0.291 | 1.03 (1.00, 1.06) | 0.160 |
| sVCAM-1 | 1.12 (1.03, 1.22) | 0.007 | 1.11 (1.02, 1.21) | 0.017 | 1.11 (1.02, 1.21) | 0.016 |
| Apoptosis and inflammation | ||||||
| IL-6 | 1.00 (0.97, 1.05) | 0.604 | 1.00 (0.96, 1.04) | 0.977 | 1.00 (0.97, 1.04) | 0.830 |
| IL-8 | 1.01 (0.97, 1.05) | 0.718 | 1.00 (0.97, 1.04) | 0.781 | 1.00 (0.97, 1,05) | 0.676 |
| sFas | 1.21 (1.16, 1.28) | 0.001c | 1.14 (1.12, 1.26) | 0.001c | 1.16 (1.05, 1.28) | 0.005c |
| sTNFR-1 | 1.06 (0.98, 1.15) | 0.144 | 1.04 (0.96, 1.13) | 0.301 | 1.05 (0.97, 1.14) | 0.235 |
Abbreviations: Ang-1 Angiopoietin 1, Ang-2 Angiopoietin 2, IL Interleukin, RR Relative risk, sFas Soluble Fas, sTNFR-1 Soluble tumor necrosis factor receptor 1, sVCAM-1 Soluble vascular cell adhesion molecule 1
aRelative risks presented per doubling of each biomarker
bAdjustment variables were as follows:
Model A: age, diabetes mellitus, body mass index
Model B: model A + Acute Physiology and Chronic Health Evaluation III
c p < 0.00625 based on Bonferroni correction for multiple hypotheses