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. 2017 Aug 17;12:140. doi: 10.1186/s13023-017-0692-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Graphical display of the delayed-start design. At baseline (time 0), patients are randomly assigned to receive either placebo (delayed-start group) or the investigational treatment (early-start group) and they are followed over an extended period of time. Then, patients in the placebo group switch to the investigational treatment until the end of the trial (active treatment phase)