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. 2017 Aug 16;36:111. doi: 10.1186/s13046-017-0581-6

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Expression and roles of ANXA2 in NB clinical samples. a. A general observation of ANXA2 expression in TMA of 42 NB samples. b, c. Five grades (0–4) of IHC staining of ANXA2 expression and proportion in NB samples (n = 42). d. ANXA2 expression is related to INSS stage of NB patients. e. ANXA2 expression is related to chemotherapy courses in NB patients. f. Kaplan-Meier survival analysis combined with Wald test of NB patients. A high level of ANXA2 was associated with poor prognosis (n = 24); a low level of ANXA2 was correlated with a longer survival time (n = 18; P = 0.008)