Table 2.
Quantification of N. meningitidis DNA in FFPE and FF tissue from patients with systemic meningococcal disease
| Patient No | Age of tissue at isolation time for DNA (years) | Type of organ | Copies N. meningitidis DNA/μg human DNA * not available |
|
|---|---|---|---|---|
| FFPE | FF | |||
| 1 | 11 | Lung | 7.9x10e5 | |
| Heart | 2.9x10e5 | |||
| Liver | 8.2x10e5 | |||
| Kidney | 5.3x10e5 | |||
| Spleen | 9.1x10e4 | |||
| Brain | 0 | |||
| 2 | 10 | Lung | 1.0x10e6 | |
| Heart | 1.3x10e6 | |||
| Liver | 2.2x10e5 | |||
| Kidney | 8.3x10e5 | |||
| Spleen | 8.1x10e4 | |||
| Brain | 0 | |||
| 3 | 5 | Lung | 2.1x10e7 | 2.4x10e8 |
| Heart | 4.6x10e7 | 4.2x10e6 | ||
| Liver | 5.8x10e5 | * | ||
| Kidney | 3.2x10e6 | 6.3x10e7 | ||
| Spleen | 1.1x10e5 | 5.9x10e6 | ||
| Brain | 0 | 5.2x10e7 | ||
| 4 | 2 | Lung | 1.2x10e9 | 2.3x10e8 |
| Heart | 1.7x10e8 | 6.1x10e7 | ||
| Liver | 3.3x10e8 | 1.2x10e8 | ||
| Kidney | 1.4x10e7 | 8.3x10e7 | ||
| Spleen | * | 4.3x10e7 | ||
| Brain | 2.8x10e5 | * | ||
| 5 | 6 | Lung | 1.5x10e7 | 4.1x10e7 |
| Heart | * | 3.5x10e7 | ||
| Liver | * | 1.7x10e7 | ||
| Kidney | * | 9.9x10e6 | ||
| Spleen | * | * | ||
| 6 | 28 | Lung | 0 | |
| Heart | * | |||
| Liver | 0 | |||
| Kidney | 0 | |||
| Spleen | 0 | |||
| Brain | 0 | |||
| 7 | 28 | Lung | 0 | |
| Kidney | 0 | |||
| Brain | 0 | |||