TABLE 1.
Characteristics of Healthy Controls and Children With Sickle Cell Anemia With and Without High Levels of Circulating Fibrocytes
| Children with SCA | ||||||
|---|---|---|---|---|---|---|
|
|
||||||
| Controls (n = 24) | SCD (n = 45) | P | Low fibrocyte (n = 39) |
High fibrocyte (n = 6) |
P | |
| Demographics | ||||||
| Age, mean (SD) | 11 (2) | 14 (5) | <0.01 | 14 (5) | 18 (4) | 0.049 |
| Gender, % female | 50 | 53 | 0.8 | 51 | 67 | 0.5 |
| Pulmonary function tests | ||||||
| FEV1 (% predicted), mean (SD) | 98 (14) | 91 (13) | 0.03 | 90 (14) | 97 (9) | 0.3 |
| FVC (% predicted), mean (SD) | 104 (14) | 96 (13) | 0.01 | 95 (13) | 102 (11) | 0.2 |
| FEV1/FVC (% predicted), mean (SD) | 88 (2) | 89 (2) | 0.10 | 83 (6) | 83 (14) | 0.97 |
| TLC (% predicted), mean (SD) | 105 (14) | 85 (18) | <0.01 | 83 (18) | 94 (9) | 0.2 |
| Laboratory values | ||||||
| Hemogloblin (g/dl), mean (SD) | — | 8.0 (1) | — | 8.1 (1) | 7.4 (0.7) | 0.1 |
| WBC (cells/µl), mean (SD) | — | 12.8 (4) | — | 12.7 (4) | 13.2 (4) | 0.8 |
| Reticulocyte %, mean (SD) | — | 12.8 (6) | — | 11.9 (5) | 19.1 (8) | 0.005 |
| Oxygen saturation %, mean (SD) | — | 97 (3) | — | 96.7 (3) | 95.8 (2) | 0.5 |
| SCD characteristics | ||||||
| Pain episodes, median (IQR) | — | 0.40 (0.9) | — | 0.41 (0.9) | 0.18 (0.8) | 0.4 |
| Acute chest syndrome, (IQR) | — | 0.28 (0.4) | — | 0.30 (0.4) | 0.17 (0.2) | 0.2 |
| Hydroxyurea, % yes | — | 52 | — | 50 | 75 | 0.3 |
| Asthma characteristics | ||||||
| Asthma, % yes | — | 47 | — | 50 | 67 | 0.5 |
| Serum IgE, median (IQR) | — | 82 (159) | — | 89 (153) | 50 (320) | 0.9 |
| Eosinophil %, mean (SD) | — | 3.7 (3) | — | 3.7 (4) | 4.2 (2) | 0.7 |
SCA, sickle cell anemia; SD, standard deviation; FEV1, forced expiratory volume in 1 sec; FVC, forced vital capacity; TLC, total lung capacity; IQR, inter-quartile range; WBC, white blood cell. Bold, P values < 0.5.