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. Author manuscript; available in PMC: 2017 Aug 17.
Published in final edited form as: Mol Cell Biochem. 2016 Jun 4;418(1-2):1–11. doi: 10.1007/s11010-016-2725-y

Fig. 3.

Fig. 3

Involvement of NADPH oxidase and mitochondria in cytosolic cytochrome c release and apoptosis. ARVMs were pretreated with NAC, APO, MnTBAP, or GLIB for 30 min followed by treatment with OPN for 6 h (a) or 24 h (b). a Cytosolic fractions were analyzed by Western blots using anti-cytochrome c antibodies. The lower panel exhibits the mean data normalized to GAPDH, *p < 0.05 versus CTL; $p < 0.05 versus OPN; n = 3–7. b Apoptosis was measured using TUNEL-staining assay, *p < 0.05 versus CTL; $p < 0.05 versus OPN; n = 6–8