Table 4.
Significant prognostic values of GRK3 expression and other variables in all patients and univariate log-rank test-identified subgroups of HCC (estimated by multivariate Cox regression test)
| Sets | GRK3 expression | Other independent prognostic factors | ||
|---|---|---|---|---|
| HR | 95%CI | P* | ||
| All patients | 0.610 | 0.436-0.853 | 0.004 | E-S grade, VI, TNM stage |
| Tumor size ≥5 cm | 0.547 | 0.370-0.809 | 0.003 | E-S grade, VI, TNM stage, AFP level |
| With VI | 0.612 | 0.400-0.937 | 0.024 | TNM stage |
| E-S grade I-II | 0.663 | 0.419-1.050 | 0.080 | VI, TNM stage |
| E-S grade III-IV | 0.538 | 0.316-0.915 | 0.022 | None |
| TNM stage III-IVA | 0.541 | 0.344-0.850 | 0.008 | AFP level |
| AFP level ≤20ng/ml | 0.632 | 0.346-1.157 | 0.137 | E-S grade |
| AFP level >20ng/ml | 0.552 | 0.365-0.835 | 0.005 | VI, TNM stage |
*Partial data were not available, and statistical analyses were performed using available data. GRK3, G-protein-coupled receptor kinase 3; HCC, hepatocellular carcinoma; HR, hazard ratio; CI, confidence interval; E-S, Edmondson-Steiner; VI, Vascular invasion; TNM, tumor-node-metastasis; AFP, α-fetoprotein.