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. 2017 Jul 5;8(11):1988–1994. doi: 10.7150/jca.18900

Figure 2.

Figure 2

Change in serum DCP levels before and 8 weeks after the beginning of treatment. (A) Patients with PR or SD of the sorafenib + vitamin K treatment group (n=14). (B) Patients with PD of the sorafenib + vitamin K group (n=8). (C) Patients with PR or SD of the sorafenib alone treatment group (n=8). (D) Patients with PD of the sorafenib alone treatment group (n=16). In the sorafenib + vitamin K group, 22 patients were available because they concurrently started sorafenib and vitamin K dosing, and serum DCP levels were tested just before and 8 weeks after the beginning of the treatment. In the sorafenib alone group, 24 patients were available because their serum DCP levels were tested just before and 8 weeks after the beginning of the treatment. The change of DCP levels (mean±S.D. [Log mAU/mL]) were 1.97±0.57 to 1.29±0.28 (P=0.002) (A), 2.90±1.32 to 1.78±0.53 (P=0.034) (B), 2.28±0.91 to 2.64±1.03 (P= 0.048) (C), and 2.65±0.95 to 3.14±1.17 (P= 0.020) (D). To evaluate the change in serum DCP levels, a paired t-test was performed for log-transformed measures with normal distribution.