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| No. of mutants observed
|
||||
|---|---|---|---|---|
| dNTP pool | T to C | T(C) to C* | Substitution | Total |
| Exonuclease-deficient pol γ | ||||
| Equimolar (1 μM) | 5 | 2 | 45 | 70 |
| Heart (SSM) | 20 | 10 | 27 | 38 |
| Heart (IFM) | 28 | 16 | 44 | 57 |
| Skeletal muscle | 27 | 14 | 58 | 65 |
| Wild-type pol γ | ||||
| Equimolar (1 μM) | 2 | 1 | 15 | 15 |
| Heart (SSM) | 5 | 4 | 21 | 23 |
| Heart (IFM) | 8 | 6 | 32 | 35 |
| Skeletal muscle | 1 | 0 | 16 | 18 |
T to C substitution with a C 5′ to the T.
