Table 2.
Multivariate Cox hazard ratio regression model of clinical parameters and soluble carrier super family expression in TCGA ccRCC cohort
| Parameters | HR | 95%CI | P* |
|---|---|---|---|
| Age | 1.045 | 1.025-1.065 | 0.000 |
| T | 0.110 | 0.059-0.206 | 0.000 |
| M | 0.365 | 0.133-1.002 | 0.050 |
| stage | 16.099 | 7.687-33.718 | 0.000 |
| Necrosis | 2.676 | 1.438-4.980 | 0.002 |
| SLC2A13 | 0.382 | 0.228-0.640 | 0.000 |
| SLC4A5 | 0.536 | 0.342-0.840 | 0.007 |
| SLC4A8 | 0.502 | 0.322-0.782 | 0.002 |
| SLC5A5 | 0.321 | 0.234-0.441 | 0.000 |
| SLC5A6 | 0.439 | 0.241-0.799 | 0.007 |
| SLC6A7 | 0.618 | 0.454-0.841 | 0.002 |
| SLC7A9 | 1.463 | 1.101-1.944 | 0.009 |
| SLC6A15 | 1.225 | 1.056-1.421 | 0.007 |
| SLC6A19 | 0.812 | 0.730-0.903 | 0.000 |
| SLC9A3R2 | 0.437 | 0.263-0.725 | 0.001 |
| SLC9A5 | 2.087 | 1.344-3.242 | 0.001 |
| SLC10A2 | 0.788 | 0.695-0.893 | 0.000 |
| SLC10A3 | 0.458 | 0.209-1.006 | 0.052 |
| SLC10A5 | 1.660 | 1.230-2.239 | 0.001 |
| SLC10A6 | 0.791 | 0.626-0.999 | 0.049 |
| SLC11A2 | 0.189 | 0.089-0.401 | 0.000 |
| SLC12A4 | 0.050 | 0.018-0.137 | 0.000 |
| SLC12A7 | 4.223 | 2.484-7.180 | 0.000 |
| SLC12A8 | 1.323 | 1.100-1.590 | 0.003 |
| SLC13A4 | 0.478 | 0.369-0.619 | 0.000 |
| SLC14A1 | 0.775 | 0.628-0.956 | 0.017 |
| SLC16A8 | 2.721 | 1.843-4.015 | 0.000 |
| SLC17A1 | 2.007 | 1.623-2.482 | 0.000 |
| SLC17A5 | 0.234 | 0.128-0.426 | 0.000 |
| SLC17A7 | 2.325 | 1.755-3.082 | 0.000 |
| SLC18A3 | 1.106 | 1.025-1.194 | 0.009 |
| SLC20A1 | 4.324 | 2.090-8.946 | 0.000 |
| SLC22A2 | 1.320 | 1.136-1.535 | 0.000 |
| SLC22A20 | 1.905 | 1.367-2.655 | 0.000 |
| SLC24A6 | 5.529 | 1.980-15.443 | 0.001 |
| SLC25A14 | 2.330 | 1.041-5.216 | 0.040 |
| SLC25A19 | 0.129 | 0.060-0.278 | 0.000 |
| SLC25A23 | 0.334 | 0.198-0.565 | 0.000 |
| SLC25A27 | 1.588 | 1.180-2.136 | 0.002 |
| SLC25A28 | 4.264 | 1.776-10.237 | 0.001 |
| SLC25A29 | 0.449 | 0.269-0.749 | 0.002 |
| SLC25A35 | 4.743 | 2.572-8.745 | 0.000 |
| SLC25A37 | 2.606 | 1.674-4.057 | 0.000 |
| SLC25A39 | 10.389 | 4.152-25.994 | 0.000 |
| SLC25A46 | 0.317 | 0.142-0.709 | 0.005 |
| SLC26A1 | 0.349 | 0.248-0.491 | 0.000 |
| SLC26A8 | 0.614 | 0.443-0.852 | 0.003 |
| SLC30A1 | 2.376 | 1.377-4.102 | 0.002 |
| SLC35A3 | 3.246 | 1.655-6.368 | 0.001 |
| SLC35B2 | 4.723 | 2.089-10.679 | 0.000 |
| SLC35B4 | 6.985 | 3.063-15.931 | 0.000 |
| SLC35D3 | 0.534 | 0.320-0.892 | 0.016 |
| SLC35E4 | 5.431 | 2.774-10.631 | 0.000 |
| SLC35F1 | 0.744 | 0.544-1.016 | 0.063 |
| SLC35F3 | 1.191 | 1.023-1.386 | 0.025 |
| SLC35F5 | 4.297 | 1.990-9.281 | 0.000 |
| SLC38A10 | 5.816 | 2.615-12.936 | 0.000 |
| SLC38A11 | 0.693 | 0.569-0.846 | 0.000 |
| SLC38A6 | 2.046 | 1.087-3.850 | 0.027 |
| SLC39A3 | 0.156 | 0.069-0.352 | 0.000 |
| SLC39A9 | 11.986 | 3.674-39.103 | 0.000 |
| SLC40A1 | 0.371 | 0.242-0.569 | 0.000 |
| SLC43A3 | 1.507 | 0.968-2.346 | 0.069 |
| SLC44A1 | 0.484 | 0.224-1.047 | 0.065 |
| SLC44A4 | 1.285 | 1.086-1.521 | 0.003 |
| SLC45A2 | 0.572 | 0.458-0.716 | 0.000 |
| SLC45A4 | 0.678 | 0.441-1.042 | 0.077 |
| SLC46A2 | 1.378 | 0.990-1.918 | 0.057 |
| SLC47A1 | 0.608 | 0.466-0.792 | 0.000 |
| SLCO2A1 | 2.505 | 1.697-3.700 | 0.000 |
| SLCO4C1 | 1.529 | 1.168-2.001 | 0.002 |
| SLCO5A1 | 0.617 | 0.455-0.835 | 0.002 |
*Parameters that were significant (p<0.01) in univariate cox regression model entered the multivariate model. Backward Cox regression procedure was used to build the multivariate model;
P<0.05 were indicated as bold type