Table 3.
Comparision of ccRCC tumors versus adjacent normal tissues in SLCs
| Gene Name | Normal(N=71) | Tumor(N=71) | Fold change | P* | Tumor expression | HRa | Survival association | ||
|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | ||||||
| SLC2A13 | 10.204 | 0.635 | 9.422 | 0.672 | 0.582 | 0.000 | down regulated | 0.382 | favourable |
| SLC4A5 | 5.558 | 0.598 | 6.246 | 0.669 | 1.610 | 0.000 | upregulated | 0.536 | favourable |
| SLC4A8 | 7.642 | 1.503 | 4.821 | 0.809 | 0.142 | 0.000 | down regulated | 0.502 | favourable |
| SLC5A5 | 0.385 | 0.479 | 0.807 | 0.731 | 1.341 | 0.000 | upregulated | 0.321 | favourable |
| SLC5A6 | 8.755 | 0.269 | 8.645 | 0.551 | 0.926 | 0.089 | down regulated | 0.439 | favourable |
| SLC6A15 | 2.694 | 1.299 | 1.313 | 2.319 | 0.384 | 0.000 | down regulated | 1.225 | poor |
| SLC6A19 | 9.841 | 3.900 | 6.768 | 3.642 | 0.119 | 0.000 | down regulated | 0.812 | favourable |
| SLC6A7 | 0.326 | 0.417 | 0.653 | 0.579 | 1.255 | 0.000 | upregulated | 0.618 | favourable |
| SLC7A9 | 7.693 | 3.520 | 8.114 | 1.797 | 1.339 | 0.384 | upregulated | 1.463 | poor |
| SLC9A3R2 | 11.025 | 0.527 | 10.640 | 1.071 | 0.766 | 0.006 | down regulated | 0.437 | favourable |
| SLC9A5 | 2.770 | 0.747 | 3.379 | 0.931 | 1.526 | 0.000 | upregulated | 2.087 | poor |
| SLC10A2 | 5.943 | 3.612 | 7.542 | 2.903 | 3.029 | 0.001 | upregulated | 0.788 | favourable |
| SLC10A5 | 3.207 | 0.969 | 3.588 | 1.381 | 1.303 | 0.039 | upregulated | 1.660 | poor |
| SLC10A6 | 1.647 | 0.824 | 4.115 | 1.348 | 5.532 | 0.000 | upregulated | 0.791 | favourable |
| SLC11A2 | 10.643 | 0.265 | 9.898 | 0.463 | 0.597 | 0.000 | down regulated | 0.189 | favourable |
| SLC12A4 | 10.279 | 0.377 | 10.773 | 0.472 | 1.408 | 0.000 | upregulated | 0.050 | favourable |
| SLC12A7 | 11.044 | 0.449 | 11.885 | 0.756 | 1.791 | 0.000 | upregulated | 4.223 | poor |
| SLC12A8 | 7.729 | 0.725 | 6.235 | 2.053 | 0.355 | 0.000 | down regulated | 1.323 | poor |
| SLC13A4 | 1.678 | 0.709 | 1.626 | 1.002 | 0.965 | 0.668 | down regulated | 0.478 | favourable |
| SLC14A1 | 9.823 | 1.744 | 6.655 | 1.440 | 0.111 | 0.000 | down regulated | 0.775 | favourable |
| SLC16A8 | 1.589 | 0.609 | 1.922 | 0.743 | 1.260 | 0.003 | upregulated | 2.721 | poor |
| SLC17A1 | 8.239 | 3.517 | 7.703 | 2.262 | 0.690 | 0.265 | down regulated | 2.007 | poor |
| SLC17A5 | 10.316 | 0.460 | 10.121 | 0.452 | 0.874 | 0.014 | down regulated | 0.234 | favourable |
| SLC17A7 | 3.830 | 0.756 | 2.589 | 0.970 | 0.423 | 0.000 | down regulated | 2.325 | poor |
| SLC18A3 | 0.126 | 0.219 | 1.733 | 2.561 | 3.047 | 0.000 | upregulated | 1.106 | poor |
| SLC20A1 | 9.739 | 0.819 | 9.347 | 0.546 | 0.762 | 0.001 | down regulated | 4.324 | poor |
| SLC22A2 | 12.165 | 0.830 | 11.981 | 1.703 | 0.880 | 0.406 | down regulated | 1.320 | poor |
| SLC22A20 | 1.668 | 0.665 | 1.267 | 1.093 | 0.757 | 0.009 | down regulated | 1.905 | poor |
| SLC24A6 | 9.610 | 0.560 | 9.401 | 0.510 | 0.866 | 0.023 | down regulated | 5.529 | poor |
| SLC25A14 | 6.558 | 0.226 | 6.819 | 0.473 | 1.199 | 0.000 | upregulated | 2.330 | poor |
| SLC25A19 | 7.333 | 0.451 | 7.597 | 0.618 | 1.201 | 0.002 | upregulated | 0.129 | favourable |
| SLC25A23 | 11.591 | 0.265 | 11.270 | 0.557 | 0.801 | 0.000 | down regulated | 0.334 | favourable |
| SLC25A27 | 6.012 | 0.722 | 5.426 | 1.157 | 0.666 | 0.000 | down regulated | 1.588 | poor |
| SLC25A28 | 8.857 | 0.223 | 9.194 | 0.449 | 1.264 | 0.000 | upregulated | 4.264 | poor |
| SLC25A29 | 9.428 | 0.516 | 7.762 | 0.758 | 0.315 | 0.000 | down regulated | 0.449 | favourable |
| SLC25A35 | 7.546 | 0.447 | 5.770 | 0.633 | 0.292 | 0.000 | down regulated | 4.743 | poor |
| SLC25A37 | 8.177 | 0.391 | 8.693 | 0.753 | 1.430 | 0.000 | upregulated | 2.606 | poor |
| SLC25A39 | 11.626 | 0.388 | 10.775 | 0.825 | 0.555 | 0.000 | down regulated | 10.389 | poor |
| SLC25A46 | 9.719 | 0.271 | 9.534 | 0.441 | 0.880 | 0.002 | down regulated | 0.317 | favourable |
| SLC26A1 | 7.260 | 1.512 | 7.080 | 1.480 | 0.883 | 0.447 | down regulated | 0.349 | favourable |
| SLC26A8 | 1.085 | 0.753 | 0.974 | 0.670 | 0.926 | 0.324 | down regulated | 0.614 | favourable |
| SLC30A1 | 9.423 | 0.496 | 8.738 | 0.797 | 0.622 | 0.000 | down regulated | 2.376 | poor |
| SLC35A3 | 9.031 | 0.347 | 8.450 | 0.584 | 0.668 | 0.000 | down regulated | 3.246 | poor |
| SLC35B2 | 10.440 | 0.311 | 10.409 | 0.442 | 0.979 | 0.630 | down regulated | 4.723 | poor |
| SLC35B4 | 9.897 | 0.338 | 9.776 | 0.414 | 0.919 | 0.054 | down regulated | 6.985 | poor |
| SLC35D3 | 0.106 | 0.236 | 0.121 | 0.254 | 1.010 | 0.736 | upregulated | 0.534 | favourable |
| SLC35E4 | 5.838 | 0.683 | 6.252 | 0.683 | 1.333 | 0.000 | upregulated | 5.431 | poor |
| SLC35F3 | 4.163 | 0.796 | 4.289 | 2.109 | 1.091 | 0.652 | upregulated | 1.191 | poor |
| SLC35F5 | 10.989 | 0.416 | 10.350 | 0.502 | 0.642 | 0.000 | down regulated | 4.297 | poor |
| SLC38A10 | 11.228 | 0.270 | 11.475 | 0.707 | 1.187 | 0.005 | upregulated | 5.816 | poor |
| SLC38A11 | 6.429 | 0.952 | 4.900 | 1.073 | 0.346 | 0.000 | down regulated | 0.693 | favourable |
| SLC38A6 | 7.186 | 0.500 | 7.535 | 0.629 | 1.274 | 0.000 | upregulated | 2.046 | poor |
| SLC39A3 | 8.554 | 0.394 | 8.042 | 0.723 | 0.701 | 0.000 | down regulated | 0.156 | favourable |
| SLC39A9 | 11.540 | 0.170 | 10.931 | 0.365 | 0.656 | 0.000 | down regulated | 11.986 | poor |
| SLC40A1 | 11.979 | 0.368 | 12.193 | 0.734 | 1.160 | 0.014 | upregulated | 0.371 | favourable |
| SLC44A4 | 10.762 | 0.714 | 7.992 | 1.768 | 0.147 | 0.000 | down regulated | 1.285 | poor |
| SLC45A2 | 1.580 | 0.779 | 2.314 | 1.551 | 1.664 | 0.000 | upregulated | 0.572 | favourable |
| SLC47A1 | 10.669 | 1.642 | 11.761 | 1.775 | 2.132 | 0.000 | upregulated | 0.608 | favourable |
| SLCO2A1 | 10.732 | 1.249 | 11.441 | 1.227 | 1.634 | 0.001 | upregulated | 2.505 | poor |
| SLCO4C1 | 11.011 | 0.531 | 11.150 | 1.221 | 1.101 | 0.325 | upregulated | 1.529 | poor |
| SLCO5A1 | 1.377 | 1.034 | 2.368 | 1.221 | 1.987 | 0.000 | upregulated | 0.617 | favourable |
*P paired t test, two side. P<0.05 were indicated as bold type
a Hazard ratio of overall survival