Table 2.

Univariate and multivariate cox hazards analysis for overall survival in 539 patients with HCC

	Univariate analysis			Multivariate analysis
Variables	HR	95%CI	p value*	HR	95%CI	p value*
Gender
Male vs. Female	1.041	0.681-1.191	0.854	1.214	0.657-2.242	0.537
Age (years)
<53 vs.≥53	0.911	0.697-1.190	0.492	1.206	0.818-1.778	0.345
TNM stage
III-IV vs. I-II	4.387	3.290-5.849	0.000
Tumor size(cm)
<5 vs.≥5	4.267	3.220-5.654	0.000	4.399	2.838-6.817	0.000
Tumor number
Single vs. Multiple	1.853	1.410-2.436	0.000	0.737	0.488-1.115	0.149
Node stage
N0 vs. N1-2	2.293	1.487-3.536	0.000	1.513	0.753-3.040	0.245
Distant metastases
Yes vs. No	1.899	1.172-3.077	0.009	1.211	0.522-2.811	0.655
BMI (kg/m2)
≥24.0 vs. 18.5-23.9 vs. <18.5	0.793	0.634-0.992	0.042	0.977	0.721-1.324	0.880
Alcohol behavior
Yes vs. No	1.000	0.757-1.321	0.999
Family history of cancer
Yes vs. No	0.732	0.527-1.017	0.063
HBV DNA
<103 vs. ≥103	2.010	1.349-2.993	0.001	1.830	1.190-2.814	0.006
AFP
<400 vs. ≥400	2.066	1.564-2.729	0.000	1.519	1.038-2.224	0.031
PT
<12.1 vs. ≥12.1	1.787	1.359-2.350	0.000	1.661	1.125-2.451	0.011
APTT
<25.6 vs. ≥25.6	1.416	1.082-1.854	0.011	1.457	0.982-2.161	0.061
Fbg
<2.83 vs. ≥2.83	2.794	2.102-3.714	0.000	2.158	1.427-3.263	0.000
TT
<18.4 vs. ≥18.4	1.009	0.772-1.319	0.948
PLT
<178 vs. ≥178	1.850	1.389-2.464	0.000	1.081	0.706-1.656	0.720

HR, Hazard ratio; 95% CI, 95% confidence interval;

*Cox hazard regression model.