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Gene expression programs activated in specified pro-B cells and their differentiated progeny (B cell precursors). E2A-, EBF-, and Pax-5-regulated genes and IgH locus DNA rearrangements are shown. Pax-5 expression is contingent on E2A and EBF. Pax-5 reinforces and expands the B lineage program of gene expression. E2A* indicates E2A activation.
