Table 1.
Patient Characteristics (n = 44)
| Characteristics | OCC (%∞) n=12 |
OPC (%∞) n=32 |
Total (%∞) | P-value |
|---|---|---|---|---|
| Age yrs (median, range) | 59 (20,82) | 60 (39,74) | 59.5 (20,82) | 0.99 |
|
| ||||
| Gender | 0.42 | |||
| Male | 8 (67) | 26 (81) | 34 (77) | |
| Female | 4 (33) | 6 (19) | 10 (23) | |
|
| ||||
| Tumor site | ||||
| Tonsil | - | 14 | 14 (32) | |
| Base of Tongue | - | 18 | 18 (41) | |
| Floor of mouth | 4 | - | 4 (9) | |
| Oral Tongue | 6 | - | 6 (14) | |
| Buccal mucosa | 1 | - | 1 (2) | |
| Gingiva | 1 | - | 1 (2) | |
|
| ||||
| Pathologic diagnosis | 0.27 | |||
| Squamous cell carcinoma | 11 (92) | 32 (100) | 43 (98) | |
| Adenoid cystic carcinoma | 1 (8) | 0 (0) | 1 (2) | |
|
| ||||
| T classification* | 0.59 | |||
| T1 | 5 (42) | 6 (19) | 11 (26) | |
| T2 | 4 (33) | 14 (45) | 18 (42) | |
| T3 | 1 (8) | 4 (13) | 5 (12) | |
| T4 | 2 (17) | 7 (23) | 9 (21) | |
|
| ||||
| N classification* | <0.001 | |||
| N0 | 5 (42) | 0 (0) | 5 (12) | |
| N1-2B | 6 (50) | 26 (84) | 32 (74) | |
| N2C | 0 (0) | 4 (13) | 4 (9) | |
| N3 | 1 (8) | 1 (3) | 2 (5) | |
|
| ||||
| Tumor stage* | ||||
| Stage I | 1 | 0 | 1 (2) | |
| Stage II | 2 | 0 | 2 (5) | |
| Stage III | 4 | 4 | 8 (19) | |
| Stage IVA | 4 | 25 | 29 (67) | |
| Stage IVB | 1 | 2 | 3 (7) | |
|
| ||||
| Radiation to the primary tumor site | <0.001 | |||
| ≥70 Gy | 2 (17) | 32 (100) | 34 (77) | |
| ≥66 Gy, <70 Gy | 7 (58) | 0 | 7 (16) | |
| ≥60 Gy, <66 Gy | 3 (25) | 0 | 3 (7) | |
|
| ||||
| Max radiation dose (Gy) to ORN site (n=42) | 0.01 | |||
| Median (range) | 67.4 (60.7, 74.9) | 72.7 (44.3, 80.9) | 70.6 (44.3, 80.9) | |
|
| ||||
| Mean radiation dose (Gy) to ORN site (n=42) | 0.52 | |||
| Median (range) | 61.6 (47.2, 62.9) | 58.3 (28.2,74.6) | 59.4 (28.2, 74.6) | |
|
| ||||
| ORN (sites) patients | 0.27 | |||
| Anterior Mandible | 1 (8) | 0 (0) | 1 (2) | |
| Posterior Mandible | 11 (92) | 32 (100) | 43 (98) | |
|
| ||||
| Clinical/Radiographic ORN | 0.66 | |||
| Clinical ORN | 9 (75) | 27 (84) | 36 (82) | |
| Radiographic ORN | 3 (25) | 5 (16) | 8 (18) | |
|
| ||||
| Duration (mos.) from completion of RT to ORN diagnosis | 0.03 | |||
| Median (range) | 36.1 (6.2,96.2) | 14.6 (0,120.2) | 19.1 (0,120.2) | |
|
| ||||
| ORN Grade | 0.30 | |||
| Grade 0 | 3 (25) | 5 (16) | 8 (18) | |
| Grade 1 | 1 (8) | 5 (16) | 6 (14) | |
| Grade 2 | 4 (33) | 18 (56) | 22 (50) | |
| Grade 3 | 4 (33) | 4 (12) | 8 (18) | |
|
| ||||
| Trigger | 1.00 | |||
| Spontaneous | 10 (83) | 26 (81) | 36 (82) | |
| Extraction | 2 (17) | 6 (19) | 8 (18) | |
|
| ||||
| Smoking | 0.66 | |||
| Current | 2 (17) | 9 (28) | 11 (25) | |
| Former | 8 (66) | 16 (50) | 24 (55) | |
| Never | 2 (17) | 7 (22) | 9 (20) | |
|
| ||||
| Alcohol use | 0.62 | |||
| Current | 8 (66) | 25 (78) | 33 (75) | |
| Former | 2 (17) | 4 (13) | 6 (14) | |
| Never | 2 (17) | 3 (9) | 5 (11) | |
|
| ||||
| Follow-up period (months) | 0.18 | |||
| Median (range) | 63.2 (27.4,118.3) | 50.4 (4.1,140.3) | 52.5 (4.1,140.3) | |
*
43 patients assessed,
∞
Percentages approximated
