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. Author manuscript; available in PMC: 2018 Aug 15.
Published in final edited form as: Circulation. 2017 May 9;136(7):646–660. doi: 10.1161/CIRCULATIONAHA.117.027290

Figure 7. NAC does not aggravate collagenase-induced hemorrhage.

Figure 7

(A) Schematic representation of the performed experiments. Mice received intravenous NAC (400 mg/kg), heparin (200 IU/kg) or an equivalent volume of saline 75 min after intrastriatal administration of collagenase (0.1 U). (B) Hemorrhage growth between 1h and 4h after collagenase injection as assessed by T2* imaging (n=5–7 per group). (C) Clinical score 4 hours, 24 hours and 72 hours post collagenase administration. (D) Time course of hematoma size as assessed by T2* weighted imaging (deoxyhemoglobin) in saline and NAC-treated mice. The black arrow indicates time of treatment injection. (E) Right: mean final hematoma volume as assessed by T2-weighted imaging at 72-hour post-collagenase injection. Left: Representative T2-weighted images of saline- and NAC-treated animals (n=6–7 per group). (* means significant versus saline).