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. 2017 Aug 1;10(8):993–1003. doi: 10.1242/dmm.026179

Fig. 6.

Fig. 6.

Induction of apoptosis results in disruption of the photoreceptor neuron pattern in DM2-106 retinae. (A-C) TUNEL labeling as a marker for apoptosis of N-16 (A), DM2-106 (B) and DM2-106+p35 (C) eye imaginal discs from third instar larvae under GMR-Gal4 control. The extent of the GMR expression domain in the larval eye disc is indicated. The arrow (B) highlights the induced apoptosis in the posterior part of the larval eye disc where GMR-Gal4 is expressed. (D) Rescue of the external eye morphology of adult DM2-106 flies expressing the caspase inhibitor p35 under GMR-Gal4 control. (E,F) GMR>DM2-106+p35 pupal retinae at 42 h APF labeled for the photoreceptor marker ELAV (E) and the cone cell marker Cut (F). Inhibition of apoptosis by co-expression of the caspase inhibitor P35 normalizes the photoreceptor and cone cell pattern in GMR>DM2-106 retinae (compare with Fig. 5B).