Fig. 4.

Mosaicism in S. aureus phages. (A) A highly mosaic segment of one of the DNA-replication modules of phages G1 and K. Related ORFs are identified by using a color code, with the percent identity shown to the left of bacteriophage K ORFs. Nonhomologous regions are evident on the dot matrix because they result in discontinuity of the diagonal plot and are shaded gray. None of the ORFs within this region, with the exception of G1 ORF 85 (HNH endonuclease) encode proteins with known function. (B) Mosaic nature of phage 47. The nucleotide sequence of phage 47 was scanned for conserved blocks of ≥50 bp showing≥98% identity with the other 26 S. aureus phages (identified to the left). Identified regions are aligned below the white box that schematically represents phage 47.