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. 2017 Aug 1;10(8):1015–1025. doi: 10.1242/dmm.028852

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — Functional analysis of the sciatic nerve in the different experimental groups. (A-F) Quantitative Catwalk™ gait analysis of motor function, including (A) swing, (B) swing speed, (C) print area, (D) stand, (E) single stance and (F) duty cycle over 3 weeks following primary surgery revealed gait impairment in the GG^high group compared to sham control, in contrast to rats of GG^low and scratch groups. *P<0.05, **P<0.01, ***P<0.001. Illustrated are the ratios as percentages between right (RH) and left hind limb (LH). n=6: scratch and sham control; n=8: GG^low; n=11: GG^high. (G) Formula for the calculation of the SFI according to Bain et al. (1989), and representative paw prints of the sham control (left) and GG^high group (right) 3 weeks after operation acquired with CatWalk™. E, experimental; N, normal; IT, intermediate toe spread; TS, toe spread; PL, print length. (H) Analysis of the SFI exhibited severe functional diminution of the sciatic nerve in the GG^high group compared to sham control starting 1 week after surgery. No severe functional deficiencies were detectable in the GG^low and scratch group; **P<0.01 GG^high compared with sham; n=6: scratch and sham control; n=8: GG^low; n=11: GG^high.