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. 2017 Aug 1;10(8):981–991. doi: 10.1242/dmm.030080

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Prepulse inhibition (PPI). The PPI results from the first screening cohort (A, n=15 per sex per genotype) and the replication cohort (B, n=15 per sex per genotype). The results show that the Meis1 knockout genotype effect on PPI was replicable when compared to wild-type littermates. Results are plotted as means±s.e.m. Genotype effects: *P<0.05, ** P<0.005, ***P<0.001 calculated by two-way ANOVA with sex as a factor, including interaction term. (C) The global effect of pramipexole 1.0 mg/kg body weight (left) and 3.0 mg/kg body weight (right) on the PPI of wild-type and heterozygous animals is shown. Results are plotted as means±s.e.m. Genotype effects: **P<0.005 calculated by two-way ANOVA with sex as a factor, including interaction term.