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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Cell Metab. 2017 Aug 1;26(2):301–309. doi: 10.1016/j.cmet.2017.07.001

Table 1.

Affinities of nutrient sensors for their amino acid substrates and corresponding plasma concentrations of those amino acids (Data from Stegink et al., 1991; Stein and Moore, 1954; Piyankarage et al., 2008)

AA AA binding protein Kd (μM) Plasma Concentration (μM) Interstitial Concentration Free Cytosolic Concentration
Fed Fasted Fed Fasted Fed Fasted
Leu Sestrin1 10–15 287 129 ? ? ? ?
Sestrin2 20 287 129 ? ? ? ?
Sestrin3 N/A 287 129 ? ? ? ?
LRS 45 287 129 ? ? ? ?
dSestrin 100 ? (mm range for other AAs) ? ? ? ?
Arg CASTOR1 30 161 97 ? ? ? ?
CASTOR2 N/A 161 97 ? ? ? ?