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. Author manuscript; available in PMC: 2017 Aug 17.
Published in final edited form as: Mol Genet Metab. 2016 Jan 22;117(4):393–400. doi: 10.1016/j.ymgme.2016.01.007

Fig. 4.

Fig. 4

Precision medicine: Treatment based on variant function studies. (A) Patch clamp results showing maximal response to glutamate and glycine in Xenopus oocytes transfected with the normal and mutant GRIN2A. Both the wild type and the mutant receptors were responsive to memantine inhibition. (Courtesy of Drs. Hongjie Yuan and Stephen F. Traynelis.) (B) Seizure frequency of the patient in response to various anti-epileptic medications. Note pronounced decrease in seizures on memantine. (Courtesy of Dr. Tyler Pierson.)