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. 2017 Aug 14;5:e3682. doi: 10.7717/peerj.3682

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©2017 Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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(A–C) Percentage of the affected miRNAs and synergistic miRNA interactions at different number of differently expressed miRNAs. n = 1, 3, or 5 means that one, three, or five miRNAs are simultaneously dysregulated. (D) Percentage of the affected miRNAs and synergistic miRNA interactions by altered miRNA expression. (E) Synergistic miRNA-miRNA interactions in cardiovascular system. The red, blue and gray lines represent interactions with synergy scores of >2.0, >1.5 and >1.0, respectively. Two hubs in the synergistic miRNA interaction network miR-1 and miR-21 were highlighted as big nodes.