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Effects of Mn2+ on drug-induced DNA cleavage mediated by wild-type gyrase and mutant enzymes. The abilities of ciprofloxacin (black), moxifloxacin (red), and 3′-(AM)P-dione (blue) to induce cleavage by wild-type (top left), S85L (top right), E89K (bottom left), or E89A (bottom right) gyrase in the presence of 1 mM Mn2+ are shown. Error bars represent the standard deviation of at least three independent experiments.
