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. Author manuscript; available in PMC: 2018 Jul 25.
Published in final edited form as: Biomater Sci. 2017 Jul 25;5(8):1537–1540. doi: 10.1039/c7bm00289k

Figure 1.

Figure 1

Building glycocalyx complexity. The hierarchical organization of sialoglycans in native glycocalyx (left) can be recapitulated in a controlled fashion via precision glycan engineering (right). Specific glycans are assembled into synthetic glycomimetic structures and primed with a lipid anchor for insertion into cell membranes. Delivery of unique glycans in pre-defined nanoscale arrangements to the cell surface allows for spatial organization of glycan activity in specific regions of the glycocalyx.