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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: J Fluor Chem. 2017 Jan 3;198:10–23. doi: 10.1016/j.jfluchem.2016.12.016

Table 5.

Thermodynamic parameters of binding of taxanes to microtubules

Compound ΔG 35°C (kJ/mol) ΔH (kJ/mol) ΔS (kJ/mol)
Paclitaxela −42.1±0.3 −51±4 −29±13
SB-T-1214 −46.6±0.6 −32±2 47±6
SB-T-12854 −47.1±0.7 −28±3 64±10