Table 2.
Comparison of Standardized Associations* of DXA-VAT and CT-VAT with Glucose Metabolism Markers, Lipid Levels and Inflammatory Serum Markers, Adjusted for Age and Enrollment Site
| Marker | Log DXA-VAT | Log CT-VAT | Chi-squared (P-Value)† | ||
|---|---|---|---|---|---|
| Parameter Coefficient | Change in R-Squaredˆ | Parameter Coefficient | Change in R-Squaredˆ | ||
| Log Homa2-ir (n=983) |
0.50 (0.43, 0.56) |
0.213 |
0.45 (0.40, 0.51) |
0.171 |
4.38 (0.04) |
| Log Fasting Insulin (n=1015) |
0.49 (0.44, 0.55) |
0.229 |
0.45 (0.40, 0.50) |
0.184 |
5.72 (0.02) |
| Log HDL (n=1042) |
−0.31 (−0.36, −0.25) |
0.091 | −0.28 (−0.34, −0.22) |
0.074 | 2.77 (0.10) |
| Log Triglycerides (n=1042) |
0.35 (0.30,0.40) |
0.117 |
0.36 (0.30, 0.41) |
0.120 | 0.23 (0.63) |
| LDL (n=1042) |
0.04 (−0.01 to 0.10) |
0.002 | 0.03 (−0.03, 0.09) |
0.001 | 0.38 (0.54) |
| TNF-alpha** (n = 225) |
0.17 (0.06, 0.27) |
0.026 |
0.15 (.04, .26) |
0.021 | 0.46 (0.50) |
| Log IL-6 (n=223) |
0.25 (0.11, 0.38) |
0.056 |
0.20 (0.07, 0.32) |
0.037 | 1.41 (0.24) |
| Log CRP (n=225) |
0.24 (0.11, 0.36) |
0.051 |
0.18 (0.05, 0.32) |
0.033 | 1.63 (0.20) |
*
Number of standard deviations change of VAT per standard deviation change of predictor. Associations significant at <0.05 are in bold
**
The standardized TNF-alpha variable was created using the square-root of TNF-alpha
ˆ
Incremental increase in variance of marker explained (R-Squared) when VAT is added to base model with covariates age and study enrollment site
†
Chi-squared and P-value to test hypothesis that parameter coefficients for DXA-VAT and CT-VAT are the same (modified Hausmann test using suest command of Stata)