Table 3.
Comparison of Standardized Associations* of DXA-VAT and CT-VAT with Glucose Metabolism Markers, Lipid Levels, and Inflammatory Serum Markers, Adjusted for Age, BMI, and Enrollment Site
| Marker | Log DXA-VAT | Log CT-VAT | Chi-sqared (P-Value)† |
||
|---|---|---|---|---|---|
| Parameter Coefficient | Change in R-Squaredˆ | Parameter Coefficient | Change in R- Squaredˆ | ||
| Log Homa2-ir (n=982) |
0.38 (0.28, 0.47) |
0.061 |
0.30 (0.24, 0.37) |
0.056 |
4.67 (0.03) |
| Log Fasting Insulin (n=1014) |
0.37 (0.29, 0.45) |
0.063 |
0.30 (0.24, 0.36) |
0.056 |
7.58 (0.006) |
| Log HDL (n=1041) |
−0.29 (−0.38, −0.21) |
0.040 | −0.22 (−0.29, −0.15) |
0.031 |
7.92 (0.005) |
| Log Triglycerides (n=1041) |
0.35 (0.28, 0.43) |
0.058 |
0.32 (0.25, 0.38) |
0.065 | 2.22 (0.14) |
| LDL (n=1041) |
0.11 (0.02, 0.20) |
0.005 | 0.06 (−0.02, 0.13) |
0.002 | 3.33 0.07 |
| TNF-alpha (n = 225) |
0.13 (−0.04, 0.30) |
0.007 | 0.10 (−0.03, 0.23) |
0.006 | 0.32 (0.57) |
| Log IL-6 (n=223) |
0.11 (−0.07, 0.29) |
0.005 | 0.07 (−0.08, 0.23) |
0.003 | 0.30 (0.58) |
| Log CRP (n=225) |
0.14 (−0.04, 0.32) |
0.009 | 0.08 (−0.08, 0.25) |
0.005 | 0.86 (0.35) |
*
Number of standard deviations change of log(VAT) per standard deviation change of predictor Associations significant at <0.05 are in bold
**
The standardized TNF-alpha variable was created using the square-root of TNF-alpha
ˆ
Incremental increase in variance of marker explained (R-Squared) when VAT is added to age, study enrollment site, and BMI.
†
Chi-squared and P-value to test hypothesis that parameter coefficients for DXA-VAT and CT-VAT are the same (modified Hausmann test using suest command of Stata)