Table 2.

Acute-phase cytokines in serum after intravenous endotoxin challenge

	0 h	3 h	6 h	24 h	P Value
TNFα	94±1	454±100	98±2	94±1	<0.0001
IL-1β	35±6	197±32	49±10	37±4	<0.0001
IFN-γ	54±32	55 ±28	50±27	55±35	NS
IL-2	130±24	79±3	130±23	133±25	NS
IL-4	82±2	84±3	83 ±3	82±3	NS
IL-5	52±0	52±1	52±0	51±0	NS
IL-6	0	3,155±1,054	24±24	0	<0.0001
IL-8	26±1	1,023±170	206 ±82	36±4	<0.0001
IL-10	87 ±0	326±41	94±2	87±0	<0.0001
MCP-1	303 ±74	18,179±2,078	5,218 ±2,794	452±58	<0.0001
MIP1α	261 ±1	581±28	300±15	266±2	<0.0001
MIP1β	100±46	13,696±1,624	2,118±570	207 ±89	<0.0001
RANTES	1,717±71	1,997±175	1,833±90	1,933±114	NS
Eotaxin	188 ±22	252±53	291±81	272±47	NS
VEGF	306±30	342±36	325±22	300±23	NS

Serum samples (means ± SE) for the following were measured at baseline (0 h) and 3, 6, and 24 h using a multiplex bead-based assay and analyzed by ANOVA for time effect: tumor necrosis factor (TNF)α; interleukin (IL)-1β, −2, −4, −6, −8, and −10; interferon (IFN)γ; regulated on activation, normal T cell expressed and secreted (RANTES); macrophage inflammatory protein (MIP)1α and −1β; monocyte chemotactic protein (MCP)-1; eotaxin; and vascular endothelial growth factor (VEGF). NS, not significant.