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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Mol Cancer Ther. 2017 Jan 30;16(4):591–600. doi: 10.1158/1535-7163.MCT-16-0352

Figure 2.

Figure 2

Prexasertib with cetuximab and IR induces early apoptosis. Annexin V apoptotic assay in UM-SCC1 (A), UM-SCC2 (B), UM-SCC6 (C), FaDu (D), UM-SCC47 (E), and UPCI:SCC090 cells (F). Cells were treated with either vehicle or 0.25 mg/mL C225 for 16 hours, then 1 or 10 nmol/L prexasertib (prexa) for 2 hours, followed by sham or 2 Gy IR. Cells were harvested at 48 hours after IR and evaluated for Annexin V positivity by flow cytometry. Shown is the mean ± SEM from one of two independent experiments performed in triplicate; *, P < 0.05; **, P < 0.01; ***, P < 0.001.