Table 4.
Change in WOMAC pain (100 mm) from baseline by study visit and injection technique.
| Injection technique | Baseline (mean ± SD) | Difference from baseline |
|||||
|---|---|---|---|---|---|---|---|
| Week 1 (mean ± SD) | Week 3 (mean ± SD) | Week 6 (mean ± SD) | Week 12 (mean ± SD) | Week 18 (mean ± SD) | Week 26 (mean ± SD) | ||
| Anterolateral (AL) | 60.6 ± 11.3 | −33.4 ± 18.8 | −40.1 ± 17.7 | −43.1 ± 16.7 | −41.2 ± 19.7 | −41.6 ± 21.9 | −43.1 ± 20.8 |
| Anteromedial (AM) | 60.1 ± 12.5 | −31.7 ± 23.0 | −36.9 ± 23.1 | −40.4 ± 23.0 | −40.5 ± 24.2 | −40.3 ± 24.5 | −42.7 ± 21.9 |
| Lateral midpatellar (LM) | 59.0 ± 11.4 | −29.2 ± 18.7 | −33.6 ± 19.0 | −35.3 ± 19.2 | −34.5 ± 19.8 | −33.6 ± 20.2 | −34.4 ± 20.0 |
| ANOVA (P value) | — | .2969 | .0621 | .0118* | .0248* | .0101* | .0009* |
| AL vs AM (P value) | — | .8182 | .4898 | .5963 | .9697 | .9059 | .9894 |
| AL vs LM (P value) | — | .2915 | .0527 | .0139* | .0608 | .0245* | .0071* |
| AM vs LM (P value) | — | .5597 | .3621 | .0868 | .0514 | .0318* | .0027* |
Abbreviations: ANOVA, analysis of variance; WOMAC, Western Ontario and McMaster Universities Arthritis Index.
Post hoc power analysis result at 12 weeks: 68%.
*
Statistically significant result (P < .05).