Table 4. Laboratory findings on admission of 1,400 critically ill neonatal calves with diarrhea categorized on survival to discharge from the hospital.
| Variable | Survivors (n = 1,087) Median (Q25/Q75) |
Non-survivors (n = 313) Median (Q25/Q75) |
P-value |
|---|---|---|---|
| Henderson-Hasselbalch acid-base model1 | |||
| Venous blood pH | 7.181 (7.030/7.314) | 7.133 (6.968/7.308) | 0.005 |
| pCO2 (mm Hg) | 47.4 (37.8/55.7) | 49.3 (40.5/59.9) | 0.001 |
| pO2 (mm Hg) | 35.7 (29.9/42.6) | 33.0 (27.1/40.0) | < 0.001 |
| HCO3- (mmol/L) | 16.7 (10.0/25.8) | 15.8 (9.6/27.4) | 0.84 |
| Base Excess (mmol/L) | -10.8 (-19.8/-0.5) | -12.4 (-21.7/0.3) | 0.15 |
| Anion gap (mEq/L) | 21.5 (13.3/27.4) | 23.5 (15.6/30.8) | < 0.001 |
| Strong ion difference acid-base model | |||
| Atot (mmol/L) | 19.8 (17.5/22.4) | 18.2 (16.1/20.8) | < 0.001 |
| SIDm (mEq/L) | 31.5 (24.7/36.8) | 31.3 (25.0/38.4) | 0.21 |
| USI (mEq/L) | -1.5 (-5.8/3.4) | -2.9 (-9.3/2.0) | < 0.001 |
| SIG (mEq/L) | -10.7 (-17.2/-1.1) | -15.0 (-21.6/-4.0) | < 0.001 |
| Electrolytes | |||
| Na+ (mmol/L) | 134.7 (129.9/140.4) | 139.5 (132.3/150.2) | < 0.001 |
| K+ (mmol/L) | 4.8 (4.3/6.0) | 5.0 (4.3/6.3) | 0.18 |
| Cl- (mmol/L) | 101 (96/107) | 104 (98/114) | < 0.001 |
| Clinical biochemical analysis | |||
| D-lactate (mmol/L) | 3.9 (0.7/9.9) | 4.6 (1.1/10.3) | 0.059 |
| L-Lactate (mmol/L) | 1.6 (0.9/3.0) | 2.1 (1.2/5.0) | < 0.001 |
| Glucose (mmol/L) | 4.4 (3.8/5.2) | 4.0 (3.0/5.1) | < 0.001 |
| Total protein (g/L) | 57.7 (50.9/65.4) | 53.0 (47.0/60.7) | < 0.001 |
| Albumin (g/L) | 29.2 (26.7/32.1) | 27.9 (25.3/31.1) | < 0.001 |
| Globulin (g/L) | 28.1 (22.8/34.8) | 24.5 (20.0/31.4) | < 0.001 |
| Phosphorus (mmol/L) | 2.9 (2.4/3.9) | 3.3 (2.5/4.4) | 0.001 |
| Urea (mmol/L) | 12.1 (7.2/21.0) | 16.8 (10.0/26.9) | < 0.001 |
| Creatinine (μmol/L) | 140 (99/262) | 182 (103/356) | < 0.001 |
| Enzyme activity2 | |||
| CK (U/L) | 340 (173/831) | 653 (261/1964) | < 0.001 |
| AST (U/L) | 54.8 (41.4/77.5) | 80.8 (54.1/133.1) | < 0.001 |
| GGT (U/L) | 110 (57.5/224.5) | 66.9 (36.8/128.6) | < 0.001 |
| GLDH (U/L) | 7.1 (4.3/13.2) | 11.2 (5.5/25.1) | < 0.001 |
| Hematologic analysis3 | |||
| PCV (%) | 40.9 (34.9/46.7) | 41.4 (34.1/48.5) | 0.37 |
| Hb (g/dL) | 12.8 (11.0/14.6) | 12.8 (10.7/15.2) | 0.60 |
| MCV (fL) | 39.8 (37.6/41.8) | 40.7 (38.1/42.9) | 0.001 |
| MCH (pg) | 12.5 (11.7/13.3) | 12.5 (11.8/13.3) | 0.52 |
| MCHC (g/dL) | 31.7 (29.6/33.3) | 31.3 (28.9/33.3) | 0.031 |
| RDW-CV (%) | 21.0 (19.6/23.0) | 20.8 (19.2/23.0) | 0.18 |
| Leukocytes (G/L) | 13.4 (9.6/18.6) | 13.2 (8.8/19.9) | 0.55 |
| Thrombocytes (G/L) | 920 (701/1171) | 845 (515/1182) | 0.001 |
pCO2 = partial pressure of carbon dioxide, pO2 = partial pressure of oxygen, Atot = non-volatile weak acids, SIDm = measured strong ion difference, USI = unidentified strong ions, SIG = strong ion gap, CK = creatine kinase, AST = aspartate aminotransferase, GGT = gamma glutamyltransferase, GLDH = glutamate dehydrogenase, PCV = packed cell volume, Hb = hemoglobin concentration, MCV = mean corpuscular volume, MCH = mean corpuscular hemoglobin, MCHC = mean corpuscular hemoglobin concentration, RDW = red cell distribution width (coefficient of variation).
1Information for pO2 was missing in 4 calves with a positive and 1 calf with a negative outcome
2Information for AST and GLDH was missing in 2 calves with a positive outcome.
3Information was missing in 13 calves with a positive and 7 calves with a negative outcome. Information for RDW-CV was missing in 24 calves with a positive outcome and 12 calves with a negative outcome.