Table 5. PD parameters of WT anti-PCSK9 antibody (F0016A) and the Fc variants (F0016B, C, D) after a single intravenous dose of 5 mg/kg to cynomolgus monkeys.
PD parameters (Emax and Tmax) was obtained by visible inspection of PD data.
| Antibody | CHOL mmol/L |
TG mmol/L |
LDL-c mmol/L |
HDL-c mmol/L |
VLDL-c mmol/L |
|
|---|---|---|---|---|---|---|
| F0016A | Emax | 2.06 | na | 0.40 | na | na |
| Tmax | 144h(D7) | na | 216h(D10) | na | na | |
| F0016B | Emax | 2.17 | na | 0.37 | na | na |
| Tmax | 144h(D7) | na | 216h(D10) | na | na | |
| F0016C | Emax | 2.61 | na | 0.49 | na | na |
| Tmax | 384h(D17) | na | 384h(D17) | na | na | |
| F0016D | Emax | 2.27 | na | 0.48 | na | na |
| Tmax | 144h(D7) | na | 72h(D4) | na | na |
na, not applicable.