Skip to main content
. 2017 Aug 17;12(8):e0183124. doi: 10.1371/journal.pone.0183124

Fig 3. Concentration-response curves to acetylcholine (ACh) before/after incubation with L-NNA (10 μmol/l) or L-NNA plus indomethacin (10 μmol/l) in phenylephrine (PE)-preconstricted renal arteries (n = 5).

Fig 3

L-NNA incubation resulted in a significant reduction in vasodilation in response to ACh in obese Zucker (OZ) rats and lean control rats (A), but the reduction was less in OZ rats than in lean rats (B). Combined treatment with L-NNA plus indomethacin did not further enhance the inhibitory effect of L-NNA. The reduction by L-NNA and indomethacin (D) was similar to that by L-NNA alone (B). Fig (C) shows the contribution of EDHF to ACh-induced vasodilation after treatment of L-NNA and indomethacin. The EDHF-mediated vasodilation was decreased in OZ rats. ** P<0.001, *P<0.05.